Biomarkers Index
| Abbreviation: | Definition: | Cancer Correlations: | Treatment Correlations: | ||
|---|---|---|---|---|---|
| c-MET | also known as mesenchymal epithelial transition factor (MET) or hepatocyte growth factor receptor (HGFR) - a proto-oncogene active in cell signaling, c-MET promotes cancer cell growth and multiplication. Cancers that may benefit from testing for this biomarker: lung (non-small cell), ovarian |
Lung, Ovarian | erlotinib (Tarceva®), gefitinib (Iressa®) |
||
| c-Kit | tyrosine-protein kinase Kit, also known as CD117 or mast/stem cell growth factor receptor (SCFR) - a proto-oncogene that interacts with cell growth factors, c-Kit plays a role in cell survival, multiplication and differentiation. Cancers that may benefit from testing for this biomarker: GIST (gastrointestinal stromal tumor), skin (melanoma), blood (acute myelogenous leukemia) |
Blood, Gastric, Skin | imatinib (Gleevec®), sorafenib (Nexavar®), sunitinib (Sutent®) |
||
| BRCA1 | Breast cancer 1, early onset - a tumor suppressor gene, BRCA1 helps to repair DNA or destroys cells if DNA cannot be repaired; its expression in many cancers can indicate potential response to certain types of therapies. Cancers that may benefit from testing for this biomarker: lung, ovarian, breast |
Breast, Lung, Ovarian | cisplatin (Platinol®) |
||
| AR | androgen receptor - part of the nuclear hormone receptor superfamily, active in cell signaling and therefore cell multiplication and growth. Cancers that may benefit from testing for this biomarker: prostate, breast, ovarian, bladder, lung (non-small cell) |
Bladder, Breast, Lung, Ovarian, Prostate | bicalutamide (Casodex®), flutamide (Eulexin®), goserelin (Zoladex®), leuprolide (Lupron®), abarelix (Plenaxis®), gonadorelin (Factrel®) |
||
| ALK | anaplastic lymphoma kinase - an enzyme that can form an oncogenic fusion gene with EML4. Cancers that may benefit from testing for this biomarker: lung (non-small cell), lymphoma (anaplastic large-cell), nervous system (familial neuroblastoma). |
Lung, Lymphoma, Nervous System | crizotinib (Xalkori®), pemetrexed (Alimta®) |
||
| BRAF | also know as v-raf murine sarcoma viral oncogene homolog B1 - a proto-oncogene in the RAF/MIL family of molecules active in MAP/ERK cell signaling, promotes cell multiplication and growth. Cancers that may benefit from testing for this biomarker: colon, skin (melanoma), lung (adenocarcinoma), thyroid (papillary thyroid carcinoma), nervous system (pleomorphic xanthoastrocytomas with and without anaplasia) |
Colorectal, Lung, Nervous System, Skin, Thyroid | cetuximab (Erbitux®), panitumumab (Vectibix®), vemurafenib (Zelboraf®) |
FISH, IHC |